Anti-c-Fos (A356) Antibody

Raised in rabbit against a conserved region of human c-Fos, this unconjugated polyclonal antibody from Antibodies.com targets the A356 epitope of the immediate-early gene transcription factor that forms part of the AP-1 complex. The reagent is supplied at 1 mg/ml in phosphate buffered saline (pH 7.2) with 0.05% sodium azide as a microbial preservative, packaged as a 100 µl vial.

Validated for western blot and immunohistochemistry workflows, the antibody recognizes c-Fos in human, mouse, and rat samples. Researchers commonly apply it to study neuronal activation, where c-Fos induction serves as a marker of stimulated neurons, as well as signal transduction, stress responses, and oncogenic transformation pathways.

Because the reagent is polyclonal, it recognizes multiple epitopes on the target, which can be advantageous for detecting c-Fos across species and in tissues where antigen accessibility varies. The unconjugated format gives laboratories flexibility to choose their own secondary antibody and detection system for immunofluorescence, chromogenic IHC, or chemiluminescent western blot protocols.