Anti-c-Fms Antibody

Affinity-purified in rabbit, this unconjugated polyclonal antibody from Antibodies.com recognizes c-Fms (CSF1R), the cell-surface receptor tyrosine kinase for macrophage colony-stimulating factor (M-CSF). The reagent is supplied at 100 µl per vial and is validated for western blot, immunohistochemistry, immunofluorescence, and ELISA across human, mouse, and rat samples.

c-Fms plays a central role in monocyte and macrophage lineage commitment, osteoclastogenesis, and the maintenance of tissue-resident macrophage populations, and it has been investigated in the contexts of inflammation, bone homeostasis, and several myeloid and epithelial tumors. Researchers use this reagent to probe CSF1R expression in cell lysates, fixed tissue sections, and cultured primary cells, supporting studies of tumor microenvironment, innate immune development, and downstream signaling following ligand binding.

Polyclonal reactivity enables recognition of multiple epitopes on the receptor, useful when assessing expression changes, alternative isoform usage, or receptor variants. The unconjugated format allows flexible pairing with HRP, biotin, or fluorophore reporter conjugates depending on the detection chemistry required.