Anti-c-FLIP Antibody

This polyclonal antibody from Antibodies.com is raised in rabbit and detects human c-FLIP (CFLAR), a master regulator of death-receptor apoptosis that competes with procaspase-8 for FADD binding at the DISC. The reagent is supplied as 100 µl of unconjugated antiserum for use in Western blot and ELISA workflows against endogenous protein in cell lysates and tissue extracts.

Researchers working on TRAIL and Fas signaling, TNF receptor superfamily activation, or the balance between apoptosis, necroptosis, and NF-κB pathway control rely on this reagent to track both the long (c-FLIP_L) and short (c-FLIP_S) isoforms whose differential expression influences tumor cell resistance to extrinsic death cues and immune cell survival decisions.