Anti-C / EBP δ / ε Antibody

This rabbit polyclonal antibody from Antibodies.com recognizes the C/EBP family transcription factors C/EBP δ (CEBPD) and C/EBP ε (CEBPE), two basic-leucine zipper regulators that share a conserved DNA-binding domain but play distinct roles in cellular differentiation and immune signaling. C/EBP δ is rapidly induced by inflammatory cytokines and contributes to acute-phase gene expression in hepatocytes and epithelial cells, while C/EBP ε is essential for terminal granulocyte maturation, with loss-of-function mutations linked to specific granule deficiency in neutrophils.

Validated for Western blot, immunohistochemistry, immunofluorescence, and ELISA workflows, the reagent is supplied as an unconjugated antisera in a 100 µl vial, supporting flexible secondary labeling or direct chromogenic detection. The antibody was raised in rabbit and shows reactivity against human, mouse, and rat samples, which enables translational comparisons of C/EBP δ/ε expression across rodent disease models and primary human tissue specimens.

Common research applications include profiling transcription factor responses in inflammation models, characterizing myeloid lineage commitment, and examining C/EBP-dependent regulatory networks in hepatic, mammary epithelial, and neuronal contexts. As a polyclonal reagent, it binds multiple epitopes on each target, an advantage when detecting isoform variants, low-abundance antigens, or partially denatured targets in archival formalin-fixed sections.