Anti-BTK Antibody

The Antibodies.com polyclonal reagent targets Bruton's tyrosine kinase (BTK), a Tec family non-receptor kinase essential for B-cell receptor signaling, B-cell maturation, and myeloid cell function. Raised in Rabbit, this unconjugated preparation is supplied as a 100 µl liquid vial and validated for western blot, immunohistochemistry, and immunofluorescence workflows on human, mouse, and rat samples.

BTK loss-of-function mutations cause X-linked agammaglobulinemia, and dysregulated BTK signaling drives B-cell malignancies such as chronic lymphocytic leukemia and mantle cell lymphoma, where approved kinase inhibitors including ibrutinib, acalabrutinib, and zanubrutinib have made BTK a clinically validated target.

The polyclonal format offers broad epitope coverage for reliable detection across BTK isoforms, while the unconjugated format permits flexible pairing with custom secondary antibodies and user-preferred fluorophore or enzyme labels. For best results, aliquot the vial upon arrival, store refrigerated, and protect from light to minimize freeze-thaw damage and preserve antibody activity.