Anti-BTK (Ab-222) Antibody

Raised in rabbit against an epitope near residue 222 of human Bruton's tyrosine kinase, this unconjugated polyclonal primary antibody from Antibodies.com detects the BTK protein in both human and mouse samples. Validated for Western blot and immunohistochemistry, the reagent supports studies of B-cell receptor signaling, B-lymphocyte maturation, and X-linked agammaglobulinemia (XLA) research models.

Supplied as 100 µl of unconjugated serum, the antibody is suited to probing endogenous BTK in whole-cell lysates, primary immune cell preparations, and formalin-fixed tissue sections. Investigators commonly apply it to track downstream phospholipase C-γ2 phosphorylation, examine BTK inhibitor responses in lymphoma cell models, and characterize B-cell development in knockout and transgenic mice. Store aliquots at -20°C and limit freeze-thaw cycles to maintain consistent performance across long-term projects.