Anti-BTBD1 Antibody

This unconjugated rabbit polyclonal IgG antibody from Antibodies.com targets BTBD1, a BTB/POZ domain-containing adaptor protein that functions as a substrate receptor for Cullin 3-based E3 ubiquitin ligase complexes. BTBD1 participates in ubiquitin-dependent protein turnover and has been described in the literature as an interactor of topoisomerase I, with reported links to BMI-associated genetic loci and metabolic regulation alongside roles in transcriptional modulation.

The reagent is validated for Western blot and flow cytometry applications and reacts with human and mouse samples, enabling cross-species expression profiling. It is supplied as a 100 µl vial of polyclonal antiserum suitable for aliquoting to minimize freeze-thaw cycles, with routine handling at 4 °C recommended between experimental runs.

Investigators working on Cullin-dependent ubiquitination, chromatin-associated adaptor complexes, or metabolic gene networks can use this reagent to examine protein abundance in whole-cell lysates by Western blot and to profile expressing populations by intracellular flow cytometry staining across multiple tissue and cell line models.