Anti-BSG Antibody

This rabbit polyclonal IgG antibody targets human BSG (Basigin), a transmembrane glycoprotein of the immunoglobulin superfamily also designated CD147 and EMMPRIN. Supplied by Antibodies.com as 50 µL of unconjugated liquid antiserum, the reagent is validated for Western blot, immunohistochemistry, immunocytochemistry, and immunofluorescence workflows.

BSG functions as an inducer of extracellular matrix metalloproteinases and as a signaling hub across lymphocyte activation, spermatogenesis, and erythrocyte maturation. Independent studies have identified BSG as the entry receptor exploited by certain coronaviruses, including SARS-CoV-1 and SARS-CoV-2, where it engages the viral spike protein to facilitate host-cell attachment. The protein's overexpression on tumor cells correlates with metastatic progression, making it a frequent subject in oncology research. Because the polyclonal mixture recognizes multiple epitopes across the BSG extracellular loop, transmembrane domain, and cytoplasmic tail, it provides robust coverage of the heavily glycosylated mature form, which migrates between approximately 28 and 65 kDa depending on tissue source and post-translational modification state.

Practical handling for this Antibodies.com reagent: aliquot the 50 µL volume on first thaw into single-use vials to limit repeated freeze-thaw cycles, store working aliquots at -20 °C, and protect from light during incubation steps to maintain antibody integrity. The unconjugated format allows flexible pairing with HRP-, biotin-, or fluorophore-conjugated secondary reagents for chromogenic Western blot, IHC, ICC, and immunofluorescence imaging on human cell lines and tissue sections. Intended for research use only, this polyclonal helps investigators track BSG biology in cancer, infectious-disease, and reproductive-tissue model systems.