Anti-BRCC3 Antibody

Raised in rabbit against the BRCA1/BRCA2-containing complex subunit 3 (BRCC3, also called BRCC36), this unconjugated polyclonal IgG primary antibody from Antibodies.com is supplied at 50 µl per vial and validated for western blot detection of the endogenous target in human, mouse, and rat samples. The reagent supports studies of DNA double-strand break signaling, homologous recombination, and innate immune regulation, where BRCC3 contributes to BRCA1 recruitment at damage foci and reshapes K63-linked ubiquitin chains on substrates such as histone H2A.

The polyclonal format presents multiple epitopes on the ~37 kDa BRCC3 protein, providing flexibility across lysate preparations from the listed reactive species and aiding reproducibility across blots of cell lines and primary tissues. Because the antibody is unconjugated, it pairs with HRP- or fluorophore-labelled secondaries of the user's choice, and the rabbit host slots into standard anti-rabbit detection workflows in most labs.

For handling, refrigerate the vial to preserve activity, avoid repeated freeze-thaw cycles, and aliquot upon first use if extended storage is expected. The unconjugated rabbit IgG is compatible with chemiluminescent and fluorescent western blot workflows on nitrocellulose or PVDF membranes.