Anti-BRCA1 (phospho S1524) Antibody - Identical to Abcam (ab194872)

This rabbit polyclonal IgG antibody from Antibodies.com selectively recognizes the BRCA1 tumor suppressor only when phosphorylated at serine 1524, a modification introduced by ATM kinase during the DNA damage response. Each vial contains 50 µl of unconjugated antibody validated for immunohistochemistry on formalin-fixed, paraffin-embedded human tissue sections. Researchers use the reagent to monitor BRCA1 activation following genotoxic insults such as ionizing radiation, UV exposure, or topoisomerase inhibition, and to investigate links between checkpoint signaling and homologous recombination repair. The polyclonal format offers broader epitope coverage than a monoclonal, while the unconjugated format permits pairing with HRP-, alkaline phosphatase-, or fluorophore-labeled secondary reagents chosen by the user. Reactivity has been confirmed for human samples only; cross-reactivity with mouse, rat, or other species has not been established by the manufacturer. The product is identical in sequence and specificity to the Abcam reference reagent catalogue ab194872. For storage, keep the antibody refrigerated in small working aliquots and protect from light to preserve phospho-epitope recognition through multiple experiments.