Anti-BRCA1 (Ab-1524) Antibody

The BRCA1 tumor suppressor protein undergoes phosphorylation on multiple residues in response to DNA double-strand breaks, and antibodies raised against specific phospho-epitopes are widely used to study ATM- and ATR-dependent signaling within the DNA damage response pathway. This polyclonal reagent from Antibodies.com targets the region around residue 1524 of human BRCA1 and is supplied as an unconjugated, rabbit-hosted preparation in a 100 µl vial.

Validated for Western blot and immunofluorescence, the antibody detects endogenous BRCA1 in human cells and tissue samples. Researchers commonly apply it to investigate homologous recombination repair, cell cycle checkpoint activation, and the molecular basis of hereditary breast and ovarian cancer susceptibility. The unconjugated format allows flexible pairing with secondary reagents matched to the researcher's preferred detection chemistry, including HRP, fluorophore, or biotin conjugates.

Store the vial at -20 °C in single-use aliquots to minimize freeze-thaw cycles, and protect from light. Brief centrifugation before opening helps recover the full volume. For research use only; not intended for diagnostic or therapeutic applications.