Anti-BMPR2 Antibody

This Antibodies.com rabbit polyclonal antibody recognizes BMPR2 (Bone Morphogenetic Protein Receptor Type 2), a serine/threonine kinase receptor of the TGF-beta superfamily that transduces BMP signals through phosphorylation of SMAD1/5/8. The unconjugated IgG reagent is supplied as 100 ug in liquid format and is validated for western blot, immunohistochemistry, and immunocytochemistry across human, mouse, and rat samples.

BMPR2 is widely studied in vascular biology, where loss-of-function mutations and dysregulated signaling are linked to heritable pulmonary arterial hypertension, endothelial dysfunction, and right ventricular remodeling. Researchers apply this reagent to map BMP pathway activity in pulmonary smooth muscle cells, endothelial monolayers, and disease-model tissues.

For best results, store the vial refrigerated at 4 degrees C for short-term use or freeze aliquots at -20 degrees C for long-term storage, avoiding repeated freeze-thaw cycles to preserve binding activity.