Anti-BIRC5 Antibody

Survivin, the protein encoded by BIRC5 (Baculoviral IAP Repeat Containing 5), is a member of the inhibitor of apoptosis family and a central component of the chromosomal passenger complex during mitosis. Its near-universal overexpression in embryonic and malignant tissues, paired with low expression in most terminally differentiated adult cells, makes it a widely studied target in cancer biology, tumor prognosis, and apoptosis regulation.

This rabbit polyclonal reagent from Antibodies.com is supplied as 100 µl of unconjugated antisera and is validated for Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) workflows. Reactivity has been confirmed against human, mouse, and rat samples, supporting translational studies that bridge murine tumor models and clinical specimens. Store aliquots frozen to limit freeze-thaw cycles, and protect from light when working with fluorescent secondary reagents downstream.

Researchers apply this antibody to track Survivin abundance across proliferating versus quiescent cell populations, score mitotic index in tissue sections, and probe drug-induced changes in IAP family signaling.