Anti-BIRC3 Antibody

This primary antibody from Antibodies.com is a mouse monoclonal reagent that specifically recognizes BIRC3, also known as cIAP2, a member of the inhibitors of apoptosis protein family involved in NF-κB signaling, tumor necrosis factor receptor pathways, and innate immune regulation. The unconjugated antibody is supplied as 100 µl of purified immunoglobulin formulated in 0.1 M Tris-Glycine buffer (pH 7.4) containing 150 mM NaCl, 0.2% sodium azide, and 50% glycerol as a cryoprotectant, and it is validated for Western blot detection of endogenous human and non-human primate target protein in whole-cell and tissue lysates.

BIRC3 expression is frequently investigated in studies of chronic lymphocytic leukemia, MALT lymphoma, and other B-cell malignancies, as well as in inflammation, cytokine signaling, and cell-survival research. Researchers using this reagent can probe lysates to examine cIAP2 induction downstream of TNF receptor activation or to characterize disease-associated mutations and splice variants. The monoclonal format provides batch-to-batch consistency for reproducible immunoblotting across multiple experiments, and the buffer composition is compatible with standard HRP- or fluorescence-conjugated secondary antibodies on nitrocellulose or PVDF membranes.