Anti-BIM (Ab-69) Antibody

Rabbit polyclonal antibody raised against a peptide region spanning residue 69 of human BIM (BCL2L11), a pro-apoptotic BH3-only member of the Bcl-2 family that couples survival signals to mitochondrial apoptosis. Distributed by Antibodies.com, the reagent targets the isoform region implicated in cytokine withdrawal, T-cell selection, and oncogenic stress.

Validated for Western blot and immunohistochemistry on human, mouse, and rat samples, the unconjugated polyclonal antibody is supplied as 100 µl of serum, providing enough volume for multiple membranes and tissue-staining runs. End users titrate the reagent against their own secondary detection systems.

BIM induction is read out as the commitment of cells to death, driven by sequestration of anti-apoptotic Bcl-2 relatives and direct activation of BAX and BAK at the outer mitochondrial membrane. The splice isoforms detected by the antibody span approximately 15 kDa (BIM-S) to 23 kDa (BIM-L), supporting studies of variant-specific regulation in cancer biology, immunology, and neuroscience.