Anti-BFSP1 Antibody

This rabbit polyclonal IgG antibody from Antibodies.com targets BFSP1 (Beaded Filament Structural Protein 1), the lens-specific intermediate filament protein also known as filensin. Raised in rabbit and supplied as an unconjugated reagent, it is validated for Western blot detection of BFSP1 in human, mouse, and rat samples.

BFSP1 assembles with phakinin (BFSP2/CP49) into the beaded filament cytoskeleton of differentiating lens fiber cells, where it contributes to the optical clarity of the eye lens. Loss-of-function variants in BFSP1 have been linked to autosomal dominant and recessive forms of congenital cataract, making this reagent useful for ophthalmology and vision research groups studying lens fiber cell differentiation, cytoskeletal assembly, and cataract pathogenesis.

The antibody is provided in a 200 µl volume, allowing multiple immunoblot runs, and can be paired with HRP- or fluorophore-conjugated secondary antibodies for chemiluminescent or fluorescent readout. Store refrigerated to preserve polyclonal activity, and aliquot if repeated freeze-thaw cycles are anticipated.