Anti-BEST1 Antibody

Raised in rabbit against the BEST1 (Bestrophin 1) calcium-activated chloride channel, this unconjugated polyclonal reagent from Antibodies.com supports western blot and immunohistochemistry workflows on human samples. BEST1 localizes predominantly to the basolateral plasma membrane of retinal pigment epithelial (RPE) cells, where it contributes to calcium-dependent chloride conductance and subretinal fluid homeostasis, and loss-of-function variants in the BEST1 gene are linked to Best vitelliform macular dystrophy as well as autosomal recessive bestrophinopathy. The antibody is supplied as 100 µl of liquid antiserum, unconjugated for flexible secondary-label choice, and is validated for WB and IHC applications with reactivity confirmed against human targets. Investigators working on RPE ion transport, ocular channelopathies, and the molecular pathology of inherited macular dystrophies use this reagent to probe BEST1 expression in retinal sections and epithelial lysates. Storage at 4°C is appropriate for short-term use, and aliquoting before freezing is advised to limit freeze-thaw cycles and preserve binding activity across extended experiments.