Anti-Beclin 1 (R238) Antibody

Raised in rabbit against an epitope mapping near residue R238 of human Beclin 1 (BECN1/ATG6), this unconjugated polyclonal antibody is supplied by Antibodies.com as a 50 µl aliquot at 1 mg/ml in phosphate-buffered saline containing 0.05% sodium azide at approximately pH 7.3. Beclin 1 is a core component of the class III PI3K complex that drives autophagosome biogenesis, and altered expression or post-translational modification of this protein is widely studied in tumor-suppressor pathways, neurodegenerative disease models, and cardiac remodeling research.

Validated for Western blot detection across human, mouse, and rat sample backgrounds, this reagent supports chemiluminescent and fluorescence-based secondary detection without spectral interference from a covalently attached reporter. Researchers commonly deploy it to monitor autophagic flux, BCL2-BECN1 dissociation dynamics, and mTOR-related signaling crosstalk in apoptosis studies and cell-stress response assays.

Handle the vial under refrigerated conditions short term; aliquot before long-term storage at -20°C and avoid repeated freeze-thaw cycles. The included sodium azide preservative should be considered when downstream applications involve live-cell or in vivo workflows.