Anti-Beclin 1 (R238) Antibody

Autophagy research depends on reliable detection of Beclin 1 (BECN1), a 60 kDa regulator that forms the class III PI3K complex to nucleate autophagosome membranes. This polyclonal antibody, raised in rabbit against an epitope mapping near residue R238 of Beclin 1, is supplied at 1 mg/ml in PBS with 0.05% sodium azide at approximately pH 7.3. It is validated for Western blot detection of endogenous BECN1 in human, mouse, and rat samples. Researchers studying cell signaling, cancer biology, and neurodegeneration employ Antibodies.com reagents to track autophagosome biogenesis and BECN1-mediated tumor suppressor activity. Each vial delivers 100 ul of unconjugated antibody for flexible pairing with custom secondary reagents. Aliquot upon arrival and store at -20 degrees C, avoiding repeated freeze-thaw cycles to preserve binding activity.