Anti-Beclin 1 Antibody

This rabbit polyclonal reagent targets Beclin 1, the 60 kDa coiled-coil autophagy protein encoded by BECN1 that nucleates the class III PI3K/Vps34 complex during autophagosome formation. Supplied by Antibodies.com at 100 µl, the unconjugated antibody is formulated at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide at approximately pH 7.3, and is validated for Western blot (WB) and immunohistochemistry (IHC) applications across human, mouse, and rat samples. Researchers use it to track endogenous Beclin 1 expression in cell lysates and fixed tissue sections, supporting studies of apoptosis, mitophagy, tumor suppression, and neurodegenerative disease models. Aliquot upon first use and store refrigerated to preserve activity; protect from light and avoid repeated freeze-thaw cycles. The polyclonal format yields recognition of multiple epitopes, which is useful when probing conformational variants or post-translationally modified Beclin 1 species in cell culture and tissue preparations.