Anti-BCL2L14 Antibody

BCL2L14 is a pro-apoptotic member of the BCL-2 family of apoptosis regulators, also referred to as BCL-G, that participates in mitochondrial cell death pathways through BH3 domain-mediated interactions. The protein has been studied in spermatogenesis, where one isoform shows gonad-restricted expression, and in oncology contexts, with altered levels reported in colorectal, hepatocellular, and gastric tumor tissues where it modulates apoptotic responses to chemotherapeutic stress.

This unconjugated rabbit polyclonal reagent from Antibodies.com is supplied at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, packaged as a 100 µl vial suitable for multiple Western blot and immunohistochemistry experiments. Validation on human samples supports detection of endogenous BCL2L14 in cell lysates and formalin-fixed tissue sections.

For best stability, store the vial at -20°C and protect from light, with the glycerol component preventing freezing at this temperature; aliquoting after first use helps minimize freeze-thaw cycles. Researchers can apply the antibody to investigate mitochondrial apoptosis regulation, BCL-2 family protein interactions, and potential tumor suppressor functions in their disease models.