Anti-BCL2L13 Antibody

This rabbit polyclonal IgG reagent from Antibodies.com targets BCL2L13, a member of the Bcl-2 family that localizes to mitochondria and modulates both apoptotic signaling and autophagy pathways. The unconjugated antibody is supplied as 100 µl of ready-to-use reagent and is validated for Western blot (WB) and immunofluorescence (IF) applications on human samples. Because the antibody is polyclonal, it recognizes multiple epitopes on BCL2L13, supporting reliable detection across varied experimental preparations and lysate conditions. BCL2L13, also known as BCL-RAMBO, is a single-pass transmembrane protein anchored in the outer mitochondrial membrane that carries a non-classical BH domain rather than the canonical BH1, BH2, BH3, and BH4 motifs of related Bcl-2 members, giving it a distinct mechanism of action. Investigators studying mitochondrial apoptosis, mitophagy, cancer cell death, and stress responses use anti-BCL2L13 antibodies to examine changes in expression, subcellular localization, and protein-protein interactions under pro-death or nutrient-stress conditions. The unconjugated rabbit IgG format allows flexible pairing with a wide selection of labeled secondary antibodies, accommodating colorimetric, fluorescent, and chemiluminescent detection platforms in standard immunodetection workflows.