Anti-BCL11A Antibody

BCL11A is a C2H2-type zinc finger transcription factor with central roles in lymphoid lineage commitment, neuronal development, and the developmental silencing of fetal hemoglobin (HbF) in adult erythroid cells. This rabbit polyclonal IgG antibody from Antibodies.com is raised against BCL11A, recognizes both the human and mouse protein, and is validated for Western blot detection in standard immunoblotting workflows.

Provided as a 200 µl aliquot of unconjugated antiserum, the reagent fits typical loading schemes for whole-cell or nuclear lysates and can be paired with HRP- or fluorophore-conjugated secondary antibodies for chemiluminescent or fluorescent readout. The polyclonal format increases the likelihood of recognizing multiple epitopes on the target, which is helpful when probing transcription factor expression levels or resolving isoform-specific bands on SDS-PAGE.

Common research applications include studies of the fetal-to-adult hemoglobin switch for sickle cell disease and beta-thalassemia, B-cell lymphoma biology, hematopoietic stem cell differentiation, and neurodevelopmental gene regulation. The unconjugated format also leaves open the option to couple the antibody to dyes or beads for custom detection assays in immunology and molecular hematology laboratories.