Anti-Bcl-x Antibody

This rabbit polyclonal reagent from Antibodies.com targets the Bcl-x protein, a BCL2 family member that governs mitochondrial outer membrane permeabilization and the balance between survival and apoptotic signaling in mammalian cells. Provided as an unconjugated 100 µl volume, the antibody is raised in rabbit and validated for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows across human, mouse, and rat samples.

In western blot applications it produces a band near the expected ~30 kDa position for the Bcl-xL isoform, while immunohistochemistry on formalin-fixed tissue sections reveals cytoplasmic staining patterns consistent with the protein's mitochondrial association. Researchers studying chemoresistance, DNA damage responses, or developmental cell death commonly use this reagent to probe how shifts in Bcl-x expression alter sensitivity to intrinsic apoptosis triggers. Because the host species is rabbit, the antibody can be paired with mouse or goat secondary reagents in multiplex labeling without species cross-reactivity concerns.