Anti-Bcl-2 Antibody

This unconjugated mouse monoclonal reagent from Antibodies.com is supplied as 100 µl of purified antibody validated for western blot (WB) and immunohistochemistry (IHC). Bcl-2 is an integral membrane protein anchored to the outer mitochondrial membrane, where it suppresses programmed cell death by binding and sequestering pro-apoptotic Bax and Bak effectors. The antibody cross-reacts with human, mouse, and rat Bcl-2 orthologs, supporting translational studies of mitochondrial survival signaling, chemoresistance mechanisms in lymphoma and solid tumors, and the t(14;18) chromosomal translocation that defines follicular lymphoma. Because the reagent is unconjugated, it pairs flexibly with HRP, biotin, or fluorophore secondary antibodies for chromogenic DAB detection, immunofluorescence staining, or multiplexed tissue imaging. Aliquot upon arrival to limit freeze-thaw cycles, refrigerate for short-term use, and freeze at -20 °C for long-term archival storage.