Anti-BCL-2 (Ab-56) Antibody

BCL-2 is a 26 kDa mitochondrial protein that blocks programmed cell death, and its overexpression is a defining feature of follicular lymphoma and a recognised resistance mechanism in many solid tumours. The unconjugated rabbit polyclonal Anti-BCL-2 (Ab-56) antibody from Antibodies.com detects this regulator across Western blot, immunohistochemistry, and immunofluorescence workflows on human samples.

Produced in rabbit and affinity-purified against the human BCL-2 antigen, the reagent is supplied as a 50 µL liquid aliquot and is unconjugated, so users can pair it with HRP-, biotin-, or fluorophore-conjugated secondaries of their choice. Recommended storage is -20 °C in working aliquots to limit freeze-thaw cycles, with brief handling on ice acceptable for active vials.

In Western blot, the antibody resolves the endogenous ~26 kDa BCL-2 band from whole-cell lysates. On formalin-fixed paraffin-embedded sections, immunohistochemistry produces cytoplasmic staining consistent with outer mitochondrial membrane association, supporting studies of lymphoid neoplasms and other BCL-2-driven malignancies. The unconjugated format also enables immunofluorescence co-localisation experiments with mitochondrial markers and additional apoptosis regulators.

Validation covers human reactivity in WB, IHC, and IF, giving the antibody broad utility across apoptosis research, haematopathology, and translational oncology programmes.