Anti-BCKD Antibody

Produced in rabbit as a polyclonal reagent, this unconjugated antibody recognizes the branched-chain α-ketoacid dehydrogenase (BCKD) complex, the mitochondrial enzyme responsible for oxidative decarboxylation of α-ketoacids derived from leucine, isoleucine, and valine. Antibodies.com supplies the reagent in a 100 µl vial validated for western blot and immunofluorescence detection in human, mouse, and rat samples. Investigators working on branched-chain amino acid catabolism, BCKD regulatory phosphorylation, or the molecular pathology of maple syrup urine disease (MSUD) rely on this reagent to track E1 subunit abundance in cell and tissue lysates. The polyclonal formulation is useful when probing multiple epitopes on the multimeric E1 component, supporting studies of complex assembly, kinase-mediated inactivation by BCKDK, and reactivation by the mitochondrial phosphatase PPM1K.