Anti-BAMBI Antibody

BMP and Activin Membrane-Bound Inhibitor (BAMBI) is a membrane-anchored pseudoreceptor that lacks an intracellular kinase domain and modulates signaling through the TGF-β superfamily, including BMP and activin ligands. By forming inactive complexes with type I receptors, BAMBI influences downstream Smad activation, intersects with the Wnt/β-catenin pathway through interactions with Frizzled receptors, and has been implicated in hepatic fibrogenesis, adipogenesis, colorectal and hepatocellular carcinoma progression, and inflammatory signaling. Antibodies.com distributes this Anti-BAMBI Antibody as a rabbit polyclonal IgG reagent, with verified reactivity against human and rat orthologs.

The unconjugated antibody is validated for western blot and immunofluorescence workflows, supporting visualization of BAMBI in cell lysates, tissue homogenates, and fixed sections. The 50 µl vial format pairs cleanly with HRP- or fluorophore-conjugated secondary antibodies in indirect detection schemes; aliquoting on arrival and storage at -20 °C is the standard practice for IgG reagents to limit freeze-thaw cycles. Applications include characterization of TGF-β pathway activity in liver injury models, assessment of pseudoreceptor expression in tumor samples, and basic research into developmental patterning.