Anti-BAG5 Antibody

The BAG5 protein, a member of the BCL2-associated athanogene family, is a co-chaperone characterized by four tandem BAG domains rather than the single domain found in most BAG family members. This polyclonal antibody from Antibodies.com is raised in rabbit and reacts with the human, mouse, and rat BAG5 orthologs, supporting cross-species studies of apoptosis regulation and neurodegeneration.

Provided as a 100 µl aliquot of unconjugated IgG, the reagent is intended for Western blot detection of endogenous BAG5 in cell lysates and tissue homogenates. BAG5 has attracted significant scientific interest because it interacts with the E3 ubiquitin ligase parkin and modulates mitochondrial stress responses, with published studies implicating it in dopaminergic neuron survival and cellular models of Parkinson disease.

Researchers investigating mitophagy, PINK1/parkin signaling pathways, or the cellular response to proteotoxic stress can apply this antibody to validate knockout and overexpression phenotypes, and to monitor BAG5 expression changes across disease models and treatment conditions. Storage at -20 °C in working aliquots helps preserve activity across multiple experiments.