Anti-BAG3 Antibody

Polyclonal rabbit antibody raised against BCL2-associated athanogene 3 (BAG3), supplied by Antibodies.com as an unconjugated primary reagent for research use only. The antibody targets the BAG3 co-chaperone, a 575-amino-acid protein that partners with Hsp70 to regulate selective autophagy, protein refolding, and cell-survival signaling under proteotoxic stress.

Validated in Western blot and immunohistochemistry workflows, the reagent detects endogenous BAG3 in lysates prepared from human and mouse samples and visualizes expression patterns in fixed tissue sections. Published literature implicates BAG3 in myxoid liposarcoma biology, cardiomyocyte stress responses, and aggregation-prone protein clearance in neurodegeneration models, supporting studies that link chaperone-network dysfunction to disease phenotypes.

Provided in a 100 µl volume as a liquid aliquot, the antibody should be stored refrigerated between uses, with handling under standard IgG precautions to preserve binding activity across multiple freeze-thaw cycles. Researchers commonly apply it to immunoblotted membranes or to paraffin-embedded and frozen tissue sections to map BAG3 distribution.