Anti-BACE2 Antibody

BACE2 is a transmembrane aspartic protease of the A1 family that shares homology with BACE1 but exhibits a distinct substrate profile and tissue distribution. Although first characterized in the context of amyloid precursor protein processing, BACE2 also cleaves pro-islet amyloid polypeptide and TMEM27 in pancreatic beta-cells, drawing interest in both Alzheimer's and type 2 diabetes research. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com is supplied as a 200 µl aliquot validated for Western blot and immunohistochemistry on human samples.

Studies using this antibody can probe the comparative biology of BACE1 and BACE2, explore APP processing pathways outside the central nervous system, and investigate beta-cell-specific proteolytic activity. Short-term refrigerated storage preserves activity; aliquot and freeze at -20°C for extended use across multiple experiments.