Anti-BACE2 Antibody

The polyclonal rabbit IgG reagent supplied by Antibodies.com specifically recognizes BACE2 (beta-site amyloid precursor protein-cleaving enzyme 2), a type I transmembrane aspartic protease that shares homology with the related beta-secretase BACE1 but displays distinct substrate preferences and tissue distribution patterns. The unconjugated antibody is provided in a 100 µl volume and is validated for Western blot (WB) and immunohistochemistry (IHC) applications on human samples, making it appropriate for investigations into amyloid precursor protein processing, neuronal and pancreatic tissue expression studies, and broader neuroscience and metabolism research. As a polyclonal reagent raised in rabbit, the antibody recognizes multiple epitopes on the human BACE2 target, which can be advantageous for detecting the protein across varying expression levels and in samples where post-translational modifications might mask individual epitopes.