Anti-B2M Antibody

Beta-2-microglobulin (B2M) is a ~12 kDa polypeptide that pairs non-covalently with the heavy chain of MHC class I molecules and is constitutively expressed on virtually all nucleated human cells. This unconjugated rabbit polyclonal antibody from Antibodies.com is supplied as 100 µl of reagent and has been validated for western blot, immunohistochemistry, and immunofluorescence workflows. Because B2M is ubiquitously and stably expressed, it is widely used in research as a housekeeping loading control alongside other routinely monitored proteins such as GAPDH or actin.

Investigators studying antigen presentation, tumor immune evasion, multiple myeloma biology, and renal tubular dysfunction routinely probe B2M levels in cell lysates, formalin-fixed tissue sections, and cultured human cell lines. The unconjugated format leaves the primary antibody free for downstream labelling with HRP, fluorophore, or biotin conjugates chosen by the user, giving flexibility across immunofluorescence double-labelling studies and chromogenic IHC protocols.