Anti-b-Catenin (Ab-37) Antibody

Beta-catenin functions as a transcriptional co-activator in the canonical Wnt signaling pathway and as a structural adapter linking E-cadherin to the actin cytoskeleton at adherens junctions. This rabbit polyclonal antibody from Antibodies.com is raised against beta-catenin and recognizes the full-length protein in cell lysates and tissue sections, supporting studies of both membrane-bound junctional pools and nuclear signaling pools.

The unconjugated reagent is supplied as 100 µl of liquid and is validated for western blot, immunohistochemistry, and immunofluorescence across human, mouse, and rat samples. Wnt-driven cancer research, particularly in colorectal and hepatocellular carcinoma, along with intestinal stem cell biology and epithelial-mesenchymal transition models, are common settings where anti-beta-catenin antibodies are deployed to follow pathway activation and subcellular redistribution.

Aliquot upon first thaw to minimize freeze-thaw cycles and store at -20 °C in working volumes. On western blot, the target band appears at the expected ~92 kDa molecular weight of beta-catenin.