Anti-AXIN1 Antibody

AXIN1 (Axis Inhibition Protein 1) is a critical scaffold component of the beta-catenin destruction complex that negatively regulates canonical Wnt signaling. This unconjugated rabbit polyclonal antibody from Antibodies.com is raised against AXIN1 and is validated for Western Blot detection in human, mouse, and rat samples. The reagent is supplied at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.2, and the 100 ul vial format supports multiple immunoblotting experiments.

AXIN1 plays essential roles in embryonic axis specification, cell cycle control, and tumor suppression. Aberrant AXIN1 expression or mutation has been reported in hepatocellular carcinoma, colorectal cancers, and medulloblastoma, making this antibody a useful reagent for researchers studying Wnt pathway dysregulation, cancer biology, and developmental signaling. As a polyclonal reagent, it binds multiple epitopes on the AXIN1 protein, supporting reliable recognition of the target in denatured whole-cell and tissue lysate preparations common to Western Blot workflows.

For handling, refrigerate the vial upon arrival and aliquot to limit repeated freeze-thaw cycles, which can reduce polyclonal antibody activity over extended storage.