Anti-AVEN Antibody

AVEN, a scaffold-like protein implicated in DNA damage response signaling and apoptosis regulation, can be detected across human, mouse, and rat lysates using this unconjugated polyclonal reagent from Antibodies.com. The product is supplied at 100 µl per vial and validated for Western blot, where it produces a band consistent with the annotated full-length AVEN isoform.

Raised in rabbit as an IgG polyclonal, this antibody recognizes multiple epitopes on AVEN, which improves robustness against post-translational modifications and isoform variation that can complicate single-clone detection. The unconjugated format lets users pair the antibody with their preferred HRP- or fluorophore-conjugated secondary for chemiluminescent or fluorescent WB workflows.

AVEN contributes to ATM/ATR-dependent checkpoint control following genotoxic stress and is broadly expressed across mammalian tissues. Researchers studying cell cycle arrest, programmed cell death, or checkpoint pathway activation rely on well-characterized anti-AVEN reagents to follow endogenous protein levels under different treatment conditions.

For handling, aliquot the antibody into working volumes upon receipt to limit freeze-thaw cycles; store the working aliquots refrigerated and keep the concentrate frozen for long-term stability, preserving binding performance across repeat blots.