Anti-AURKA Antibody

The Antibodies.com rabbit polyclonal antibody targets Aurora Kinase A (AURKA), a mitotic serine/threonine kinase essential for centrosome maturation, bipolar spindle assembly, and accurate chromosome segregation during cell division. Overexpression and gene amplification of AURKA are widely studied in solid tumor research, particularly in breast, colorectal, ovarian, and gastric cancer models where the kinase contributes to genomic instability and is explored as a proliferation and prognostic biomarker.

Supplied as 100 µl of unconjugated antisera raised in rabbit, this primary antibody is validated for Western blot and immunohistochemistry on human samples. Researchers use it to probe endogenous AURKA expression in cultured cell lysates and in formalin-fixed tissue sections, supporting studies of mitotic regulation, oncogenic signaling, and candidate therapeutic target validation. The polyclonal format provides broad epitope coverage across the kinase, useful when detecting total AURKA levels rather than a single phospho-epitope.

Each vial contains affinity-purified reagent suitable for standard immunodetection workflows; recommended starting dilutions vary by application and should be optimized empirically for each sample preparation. Refrigerate on arrival and protect from light to preserve activity across multiple freeze-thaw cycles.