Anti-ATXN7 Antibody

Ataxin-7 (ATXN7) is the protein product of a gene whose CAG-repeat expansion underlies spinocerebellar ataxia type 7 (SCA7), a progressive neurodegenerative disorder. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against the human ATXN7 sequence and cross-reacts with mouse ATXN7, enabling comparative studies of wild-type and polyglutamine-expanded ataxin-7 in patient samples and transgenic systems. The antibody is provided as 100 µl of a 1 mg/ml stock in phosphate-buffered saline (PBS) containing 15 mM sodium azide at approximately pH 7.2, and is validated for Western blot detection of endogenous protein in lysates from human and rodent sources. Researchers apply this reagent to probe STAGA chromatin-complex assembly, monitor ATXN7 aggregate formation in SCA7 models, and confirm expression of wild-type versus expanded ATXN7 constructs in transfected cell lines. Aliquot upon receipt to preserve activity across multiple freeze-thaw cycles, and protect from light. Intended for research use only.