Anti-ATXN2 Antibody

The Anti-ATXN2 polyclonal antibody from Antibodies.com is a rabbit IgG raised against the Ataxin-2 protein, supplied as an unconjugated 200 µl volume for western blot workflows on human and mouse samples.

ATXN2 is a polyglutamine-containing protein best known for its causative role in spinocerebellar ataxia type 2 (SCA2), where CAG repeat expansion drives neuronal degeneration. More recent research also links ATXN2 to amyotrophic lateral sclerosis (ALS), frontotemporal dementia, type 2 diabetes, and stress granule dynamics, making it a recurring target in neurodegeneration and RNA-binding protein studies.

The polyclonal format recognizes multiple epitopes across the full-length ~140 kDa Ataxin-2 protein, which is useful when working with denatured lysates from iPSC-derived neurons, brain tissue, or transfected cell lines. The reagent is left unconjugated, so end-users can pair the antibody with their preferred HRP, fluorescence, or biotinylated secondary reagents for tailored detection sensitivity.

Aliquoting upon first use is recommended to limit freeze-thaw cycles and preserve antibody titer across long-running projects. Researchers studying repeat-expansion disorders, stress granule biology, or mTORC1 signaling pathways can use this antibody for expression profiling, immunoprecipitation support, and validation of CRISPR or RNAi knockdown phenotypes.