Anti-ATXN1 Antibody

This unconjugated Rabbit polyclonal antibody targets ATXN1 (Ataxin-1), a protein implicated in spinocerebellar ataxia type 1 and broader transcriptional regulation through its interactions with CIC and other binding partners. Produced by Antibodies.com as part of their Primary Antibodies portfolio, the reagent is raised in rabbit and validated for Western blot (WB) and immunofluorescence (IF) workflows. Cross-reactivity is confirmed against Human, Mouse, and Rat samples, making the reagent useful for comparative studies in neurological and cellular models of polyglutamine expansion disease.

The antibody is supplied at 50 µl volume, unconjugated for compatibility with custom detection chemistries and secondary antibody pairings. Researchers commonly deploy this reagent to probe ATXN1 expression in Purkinje cells, brain lysates, and transfected cell lines expressing wild-type or expanded CAG-repeat constructs. Applications extend to characterising protein-protein interactions, mapping subcellular localisation, and quantifying endogenous ATXN1 levels in tissues affected by neurodegeneration.