Anti-ATXN1 Antibody

This rabbit polyclonal antibody from Antibodies.com targets ATXN1 (Ataxin-1), the protein whose CAG trinucleotide repeat expansion causes Spinocerebellar Ataxia Type 1 (SCA1). ATXN1 functions in transcriptional regulation through its interaction with CIC (Capicua) and participates in RNA processing pathways that support neuronal homeostasis, making it a frequent focus of neurodegeneration research.

Validated for western blot and immunofluorescence workflows on human, mouse, and rat samples, the reagent is supplied as 100 µl of unconjugated antibody in a single vial. Researchers apply this polyclonal preparation to study Purkinje cell biology, polyglutamine expansion pathology, and broader ataxia disease models. The polyclonal format recognizes multiple epitopes along the ATXN1 protein, which can be useful when comparing full-length and mutant forms in cell culture and tissue-based experiments. Storage at -20°C in single-use aliquots helps preserve activity across repeated freeze-thaw cycles.