Anti-ATXN1 Antibody

Ataxin-1 (ATXN1) is the polyglutamine-bearing protein whose expanded CAG repeat drives spinocerebellar ataxia type 1 (SCA1), a dominantly inherited cerebellar degeneration that selectively targets Purkinje cells. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com is supplied as a 200 µl vial, validated for Western blot and immunofluorescence on human, mouse, and rat samples. The polyclonal format recognizes multiple epitopes across the ATXN1 sequence, supporting detection of both wild-type and expanded polyglutamine alleles in cell lysates and tissue sections. Researchers use this reagent to map ATXN1 subcellular distribution in cerebellar Purkinje cells, characterize protein-protein interactions with the transcriptional repressor Capicua (CIC) within the ATXN1-CIC complex, and study phosphorylation-dependent regulation at Ser776 by Akt in polyglutamine disease models. Cross-reactivity across three species enables translational work comparing knockin mouse models such as Atxn1 154Q/2Q with human SCA1 patient samples.