Anti-ATP8A1 Antibody

ATP8A1 is a P4-ATPase phospholipid flippase that catalyzes the translocation of phospholipids from the outer to the inner leaflet of biological membranes, helping to maintain membrane lipid asymmetry critical for vesicle trafficking, cell signaling, and membrane curvature. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com was raised against human ATP8A1 and cross-reacts with mouse and rat orthologs, enabling comparative studies in mammalian model systems. It is validated for Western blot detection of endogenous ATP8A1 expression across human, mouse, and rat samples. Each vial contains 50 µL of antibody suitable for use in standard immunoblotting workflows; aliquot upon arrival and store at -20 °C to preserve activity, avoiding repeated freeze-thaw cycles. Researchers studying membrane biology, lipid transport, endosomal sorting, or P4-ATPase function in neural and hepatic tissues apply this antibody to investigate flippase expression, subcellular localization, and regulation in response to pharmacological or genetic perturbation.