Anti-ATP6V0D1 Antibody

The V-ATPase (vacuolar-type H+-ATPase) is a multi-subunit proton pump responsible for acidifying intracellular organelles, and ATP6V0D1 encodes the d1 subunit of its membrane-embedded V0 domain. ATP6V0D1, also referenced in the literature as ATP6D or VMA6, contributes to proton translocation and is broadly expressed across tissues that depend on regulated acidification, including the kidney, where V-ATPase activity is essential for urine acidification, and in immune and neural cells.

This unconjugated rabbit polyclonal IgG antibody from Antibodies.com is raised against ATP6V0D1 and validated for Western Blot detection in human, mouse, and rat samples. Supplied at 100 µl, the reagent is suited to research investigating lysosomal and endosomal pH regulation, receptor-mediated endocytosis, bone resorption by osteoclasts, autophagy, and mTORC1 pathway signaling, where the V0 sector's d subunit has been tied to amino acid sensing. Aliquoting upon arrival helps preserve antibody activity across multiple experiments.