Anti-ATP2B2 Antibody

This rabbit polyclonal antibody from Antibodies.com targets ATP2B2, the gene encoding plasma membrane calcium-transporting ATPase 2 (PMCA2). Raised in rabbit and supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the reagent is provided in a 100 µl volume and validated for Western blot and immunohistochemistry on mouse and rat specimens.

PMCA2 uses ATP hydrolysis to drive calcium export from the cytoplasm and is particularly enriched in cerebellar Purkinje cells, cochlear outer hair cells, and selected neuronal populations. The polyclonal format enables recognition of multiple epitopes on the target protein, which can aid detection in tissue sections where antigen accessibility varies between cell types and brain regions.

For routine handling, aliquot upon arrival to limit repeated freeze-thaw cycles and store at -20 °C; the 50% glycerol component acts as a cryoprotectant that preserves antibody activity during frozen storage, while the sodium azide additive prevents microbial growth during shorter working-use periods at 4 °C. Researchers studying intracellular calcium homeostasis, auditory hair cell biology, and cerebellar Purkinje cell neuroscience will find this unconjugated reagent a practical choice for co-localization, double-labeling, or downstream secondary detection workflows.