Anti-ATP2A2 Antibody

ATP2A2 encodes SERCA2, a P-type calcium-transporting ATPase that loads calcium into the sarcoplasmic and endoplasmic reticulum. The pump is essential for muscle relaxation, ER calcium homeostasis, and keratinocyte cell-cell adhesion. Loss-of-function variants in ATP2A2 cause Darier disease, an autosomal dominant acantholytic skin disorder, while altered SERCA2a expression is widely studied in cardiac hypertrophy and heart failure research models.

This rabbit polyclonal reagent from Antibodies.com is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, packaged as a 100 µL liquid aliquot. The unconjugated antibody was validated for western blot and immunohistochemistry on human, mouse, and rat samples, supporting studies of SERCA2 isoform expression in cardiomyocytes, skeletal muscle, epidermis, and other tissues where the pump contributes to intracellular calcium handling and ER stress responses.