Anti-ATP1B1 Antibody

This rabbit polyclonal antibody targets ATP1B1, the beta-1 subunit of the Na+/K+ ATPase pump, a membrane protein complex that establishes and maintains the sodium and potassium ion gradients powering resting membrane potential, secondary active transport, and cellular ion homeostasis in mammalian tissues. The Na+/K+ ATPase beta subunit contributes to the proper folding, stability, and plasma membrane insertion of the catalytic alpha subunit, and is widely expressed in cardiac, neural, renal, and epithelial cells, making it a frequent subject of investigation in cardiac electrophysiology, renal sodium handling, neural excitability, epithelial polarity, and certain cancer cell signaling contexts. Supplied at 100 µl in an unconjugated format, the reagent can be paired with a laboratory's preferred HRP, biotin, or fluorophore-conjugated secondary antibody for flexible detection chemistry. The polyclonal host response produces recognition of multiple epitopes across the target, which can be advantageous on fixed or denatured specimens. Antibodies.com validates this reagent for Western blot and immunohistochemistry, and cross-reactivity has been confirmed against human, mouse, and rat samples, supporting translational and comparative animal-model studies on a single reagent. Researchers should aliquot upon first use and store at -20 °C to limit repeated freeze-thaw cycles and preserve binding activity across multiple experiments.