Anti-ATM Antibody [Assigned #A10745]

ATM (Ataxia-Telangiectasia Mutated) is a PI3K-family serine/threonine kinase that acts as a master regulator of the cellular DNA damage response, particularly following double-strand breaks. This unconjugated rabbit monoclonal IgG antibody, clone A10745 from Antibodies.com, is supplied as a 50 µl vial and is validated for western blot and immunofluorescence on human samples.

Researchers working on genotoxic stress, ionizing radiation response, checkpoint signaling, p53 pathway activation, and the molecular basis of Ataxia-Telangiectasia syndrome use this reagent to probe ATM expression and the phosphorylation cascade that coordinates cell-cycle arrest, DNA repair, and apoptosis. Common downstream targets visualized alongside ATM include Chk2, p53 (Ser15), and gamma-H2AX, making the antibody useful as an anchor readout in DDR studies, radiosensitivity assays, and cell-cycle profiling experiments.

The unconjugated format leaves the antibody free for custom fluorophore or enzyme labeling, or for use in indirect detection workflows, while the monoclonal nature of clone A10745 supports lot-to-lot consistency and reproducible target recognition across experimental replicates.