Anti-ATM Antibody [Assigned #A10745]

Clone A10745 is a rabbit monoclonal IgG reagent from Antibodies.com that detects endogenous Ataxia-Telangiectasia Mutated (ATM) protein in human samples. ATM is a large serine/threonine kinase that acts as a master regulator of the DNA double-strand break response, where it coordinates cell cycle checkpoint arrest, homologous recombination repair, and downstream signaling through phosphorylation of substrates such as p53 and CHK2.

This unconjugated antibody is supplied in a 100 µL volume and is validated for Western blot and immunofluorescence applications. The unconjugated format allows flexible pairing with user-selected secondary antibodies, fluorophores, or enzyme conjugates. The host is rabbit, the isotype is IgG, and the reagent is reactive with human ATM, supporting detection of the full-length kinase band near 350 kDa on standard SDS-PAGE workflows.

Researchers studying radiation biology, genomic stability, and tumor suppressor pathways routinely rely on robust ATM detection. Loss-of-function mutations in the ATM gene cause ataxia-telangiectasia and predispose carriers to lymphoid malignancies and other cancers, which makes this antibody relevant to both basic DNA damage response studies and translational cancer research workflows that examine checkpoint integrity and radiosensitivity in patient-derived material.