Anti-ATL3 Antibody

This unconjugated Rabbit polyclonal IgG primary antibody targets ATL3 (Atlastin GTPase 3), a dynamin-like GTPase that drives homotypic fusion of endoplasmic reticulum tubules. Supplied as 100 µl working aliquots by Antibodies.com, the reagent is validated for Western Blot detection in Human, Mouse, and Rat samples, supporting comparative analysis in transfected cell lines, primary neuronal cultures, and tissue lysates used to study ER network architecture and membrane dynamics.

ATL3 sits at the centre of active neuropathy research because heterozygous mutations in the gene have been mapped to hereditary sensory and autonomic neuropathy type 1 (HSAN1) and overlapping sensory deficit phenotypes. Investigators studying the broader ER-shaping family, which includes the atlastins, REEP proteins, spastin, and reticulons, use anti-ATL3 immunoblots to track how defective GTPase activity reshapes the peripheral ER in sensory neurons and contributes to axonal degeneration. Western Blot bands cluster near the predicted molecular weight of the human protein, and the polyclonal backbone gives broader epitope coverage than a monoclonal when probing across multiple species in the same experiment.

The unconjugated format integrates cleanly into laboratories running their own HRP, fluorophore, or biotin secondary detection pipelines. Standard handling practice is to aliquot on receipt and store at -20 °C, avoiding repeated freeze-thaw cycles to preserve antibody titre. For Research Use Only.